From the bug reports, it seems to make a difference...
By default, RID pools are obtained in increments of 500.
I haven't touched anything such as reseting query cache for the year that the game has been up, I'm working with about 5000-1million rows depending on the table.
Everything is being updated constantly and things being inserted into the tables.
An occasional night on the couch may not be a big deal.
Developing a focused and effective questionnaire will help you to efficiently and accurately pinpoint the information so that you can make more informed decisions.
First, read the manual, it's written at a very easy-to-understand level.